Factorizing polygenic epistasis improves prediction and uncovers biological pathways in complex traits

Epistasis has been difficult to study in complex traits due to the statistical challenges of fitting polygenic interactions. Here, we develop a model called Epistasis Factor Analysis and demonstrate its utility for modeling epistasis effects in complex traits.

Source: The American Journal of Human Genetics - November 2, 2023 Category: Genetics & Stem Cells Authors: David Tang, Jerome Freudenberg, Andy Dahl Tags: Article Source Type: research