A novel rat model of annulus fibrosus injury for intervertebral disc degeneration

In clinical practice, acute trauma and chronic degeneration of the annulus fibrosus (AF) can promote further degeneration of the intervertebral disc (IVD). Therefore, it is critical to understand the AF repair process and its consequences on IVD. However, the lack of cost-effective and reproducible in vivo animal models of AF injury has limited research development in this field.

Source: The Spine Journal - October 2, 2023 Category: Orthopaedics Authors: Haibin Xu, Yuang Zhang, Yujie Zhang, Chao Yu, Kaishun Xia, Feng Cheng, Kesi Shi, Xianpeng Huang, Yi Li, Jiangjie Chen, Jiawei Shu, Xiaopeng Zhou, Yiqing Tao, Chengzhen Liang, Fangcai Li, Qixin Chen Tags: Basic Science Source Type: research