Tracking the cellular immune response from early premalignancy to active multiple myeloma in a new model

Eur J Immunol. 2023 Oct 23:e2350627. doi: 10.1002/eji.202350627. Online ahead of print.ABSTRACTTo calibrate a murine model to study premalignant to malignant multiple myeloma, mice were inoculated with different amounts of myeloma cells, and changes in the immune profile were tracked for over 200 days. The model highlights the development of T-cell exhaustion and suppressor before the appearance of clinical symptoms.PMID:37872778 | DOI:10.1002/eji.202350627
Source: European Journal of Immunology - Category: Allergy & Immunology Authors: Source Type: research