31. Prognostic significance of copy number gain of MYC detected by FISH analysis in large B-cell lymphoma

Current diagnostic workup of large B-cell lymphomas (LBCLs) includes FISH and immunohistochemistry (IHC) results. MYC translocations have negative effect on survival, are recurrent in LBCL and if detected together with BCL2 and/or BCL6 translocations, define a distinct entity of high-grade B-cell lymphoma based on the WHO classification, whereas lymphomas with high Myc and Bcl2 protein levels without MYC translocations (double-expressors) remain in the category of LBCLs. Currently there is no consensus on prognostic significance of gains of extra MYC copies, also frequently detected by FISH assay.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research