37. Cell-type-specific genetic-to-epigenetic relationships in the human breast

Interplay between the genome and the epigenome is fundamental to cell type functionality and the mechanisms of associated diseases. Most studies that have explored these interactions have leveraged population-scale genotype surveys to associate genetic polymorphisms with epigenetic states in whole blood or other heterogenous tissue types. Epigenetic states differ by cell type, raising the possibly of cell-type-specific genetic-to-epigenetic relationships that could drive specific functional states and disease predisposition.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research