Interleukin-6 reduces spheroid sizes of osteophytic cells derived from osteoarthritis knee joint via induction of apoptosis

Osteophyte in osteoarthritis (OA) joints contributes to restriction of joint movement, joint pain, and OA progression, but little is known about regulators of osteophyte. By examining the expression of the genes related to cartilage extracellular matrix (ECM), endochondral ossification and growth factor-signaling in articular cartilage and osteophyte obtained from OA knee joints, we demonstrated that several genes such as COL1A1, VCAN, BGLAP, BMP8B, RUNX2, and SOST are overexpressed in osteophyte compared to articular cartilage.

Source: American Journal of Pathology - October 31, 2023 Category: Pathology Authors: Yoshifumi Negishi, Arepati Adili, Susana de Vega, Masahiro Momoeda, Haruka Kaneko, Mehmet Zeynel Cilek, Chiho Yoshinaga, Kazuaki Takafuji, Yuta Otsuka, Masayuki Shimoda, Takako Negishi-Koga, Muneaki Ishijima, Yasunori Okada Tags: Regular Article Source Type: research