METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility

CONCLUSIONS: METTL3-regulated m6A promotes YTHDF2-mediated decay of FOXO1 mRNA, thereby affecting cellular decidualization and embryo implantation. These findings provide novel insights into the development of therapies for women with endometriosis-related infertility.PMID:37891533 | DOI:10.1186/s12958-023-01151-0

Source: Reproductive Biology - October 27, 2023 Category: Reproduction Medicine Authors: Xiaoou Li Jie Jin Xuefeng Long Ruiwen Weng Wenqian Xiong Jiaxin Liang Junjun Liu Jingwen Sun Xueqin Cai Ling Zhang Yi Liu Source Type: research