Analyzing omics data by feature combinations based on kernel functions

J Bioinform Comput Biol. 2023 Oct 18:2350021. doi: 10.1142/S021972002350021X. Online ahead of print.ABSTRACTDefining meaningful feature (molecule) combinations can enhance the study of disease diagnosis and prognosis. However, feature combinations are complex and various in biosystems, and the existing methods examine the feature cooperation in a single, fixed pattern for all feature pairs, such as linear combination. To identify the appropriate combination between two features and evaluate feature combination more comprehensively, this paper adopts kernel functions to study feature relationships and proposes a new omics data analysis method KF-[Formula: see text]-TSP. Besides linear combination, KF-[Formula: see text]-TSP also explores the nonlinear combination of features, and allows hybridizing multiple kernel functions to evaluate feature interaction from multiple views. KF-[Formula: see text]-TSP selects [Formula: see text] 0 top-scoring pairs to build an ensemble classifier. Experimental results show that KF-[Formula: see text]-TSP with multiple kernel functions which evaluates feature combinations from multiple views is better than that with only one kernel function. Meanwhile, KF-[Formula: see text]-TSP performs better than TSP family algorithms and the previous methods based on conversion strategy in most cases. It performs similarly to the popular machine learning methods in omics data analysis, but involves fewer feature pairs. In the procedure of physiological and...
Source: Journal of Bioinformatics and Computational Biology - Category: Bioinformatics Authors: Source Type: research