In silico analysis shows that dynamic changes in curvature guide cell migration over long distances

This study extends a previous in-silico model to explore the effects over time of changing the substrate curvature on cell migration guidance. By simulating a dynamic surface curvature using traveling wave patterns, we investigate the influence of wave height and speed, and find that long-distance cell migration guidance can be achieved on specific wave patterns. We propose a mechanistic explanation of what we call dynamic curvotaxis and highlight those cellular features that may be involved. Our results open a new area of study for understanding cell mobility in dynamic environments, from single-cell in vitro experiments to multi-cellular in vivo mechanisms.PMID:37875692 | DOI:10.1007/s10237-023-01777-4
Source: Biomechanics and Modeling in Mechanobiology - Category: Biomedical Science Authors: Source Type: research