Assessing potential of psilocybin for depressive disorders

Expert Opin Investig Drugs. 2023 Oct 23. doi: 10.1080/13543784.2023.2273493. Online ahead of print.ABSTRACTINTRODUCTION: There has been increasing interest in the role psilocybin may play inthe treatment of depressive disorders. Several clinical trials haveshown psilocybin to have efficacy in reducing symptoms of depression.AREASCOVERED: We discuss the current understanding of psilocybin'stherapeutic mechanism of action and review existing clinical datainvestigating psilocybin as a novel therapeutic agent for thetreatment of depression.EXPERTOPINION: There is still much unknown regarding the risks ofpsilocybin treatment. When weighing the known risks and benefits ofpsilocybin treatment against those found in existing standards ofcare, among patients with depression, patients withtreatment-resistant depression (TRD) may be the most suitablecandidates for psilocybin treatment at this time.PMID:37869790 | DOI:10.1080/13543784.2023.2273493
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Authors: Source Type: research