The relationship between EMG high frequency and low frequency band amplitude changes correlates with tissue inorganic phosphate levels

In this study, we attempted to derive a non-invasive biomarker for phosphate tissue levels. We analyzed surface electromyography signals taken during 31P spectroscopy of leg muscles in five adult pigs. We induced hypophosphatemia via 20 minutes-long hyperventilation. It turned out that the proportion of the amplitude of the low frequency band and the high frequency band is significantly (p=0.002) correlated with the relative phosphate levels. The electromyographic signal did not correlate significantly with pCO2 levels in the blood, suggesting that the changes in the signal are a result of inorganic phosphate levels, not hyperventilation. The results might lead to the development of a real-time phosphate fluctuations measurement procedure.PMID:37851507 | DOI:10.18388/abp.2020_6893

Source: Acta Biochim Pol - October 18, 2023 Category: Biochemistry Authors: Ma łgorzata Habich Bartosz Pawlinski Kamil Lorenc Maria Sady Katarzyna Siewruk Piotr Zielenkiewicz Zdzislaw Gajewski Jaroslaw Poznanski Leszek Paczek Pawel Szczesny Source Type: research