Complete response of glottic cancer to intra-arterial infusion chemotherapy combined with radiotherapy: A report of 4 cases

Radiol Case Rep. 2023 Oct 14;18(12):4514-4521. doi: 10.1016/j.radcr.2023.09.058. eCollection 2023 Dec.ABSTRACTSurgical resection is recommended for advanced-stage, resectable glottic cancer. However, total laryngectomy results in the loss of vocal function and reduces patients' quality of life. At our institution, patients with cT3N0M0 stage III resectable glottic cancer who wish to preserve their larynx are treated with super-selective cisplatin infusion with concomitant radiotherapy (RADPLAT) to improve local control over systemic chemotherapy. Herein, we present 4 patients with glottic cancer who underwent biweekly intra-arterial infusion chemotherapy combined with radiation therapy 3 times. For intra-arterial infusion chemotherapy, 100 mg cis-diaminodichloroplatinum was infused into the superior thyroid artery, including the superior laryngeal artery branch. Thereafter, intensity-modulated radiation therapy was administered at doses of 70 Gy in 35 fractions for 3 patients and 66 Gy in 33 fractions for 1 patient. These patients showed complete response after chemoradiotherapy with no recurrence or metastases during the follow-up period to date (mean follow-up period: 56 months, range: 39-76 months).PMID:37876893 | PMC:PMC10590759 | DOI:10.1016/j.radcr.2023.09.058

Source: Cancer Control - October 25, 2023 Category: Cancer & Oncology Authors: Ryo Yamakuni Hirofumi Sekino Masakazu Ikeda Yoshiki Endo Masamitsu Ikeda Shiro Ishii Kenji Fukushima Shigeyuki Murono Yoshiyuki Suzuki Hiroshi Ito Source Type: research