The role of transposable elements in human evolution and methods for their functional analysis: current status and future perspectives

Genes Genet Syst. 2023 Oct 20. doi: 10.1266/ggs.23-00140. Online ahead of print.ABSTRACTTransposable elements (TEs) are mobile DNA sequences that can insert themselves into various locations within the genome, causing mutations that may provide advantages or disadvantages to individuals and species. The insertion of TEs can result in genetic variation that may affect a wide range of human traits including genetic disorders. Understanding the role of TEs in human biology is crucial for both evolutionary and medical research. This review discusses the involvement of TEs in human traits and disease susceptibility, as well as methods for functional analysis of TEs.PMID:37866889 | DOI:10.1266/ggs.23-00140

Source: Genes and Genetic Systems - October 22, 2023 Category: Genetics & Stem Cells Authors: Kei Fukuda Source Type: research