Comparison of the effect of daily vitamin D2 and vitamin D3 supplementation on serum 25-hydroxyvitamin D concentration (total 25(OH)D, 25(OH)D2 and 25(OHD3) and importance of body mass index: a systematic review and meta-analysis

CONCLUSIONS: D3 leads to a greater increase of 25(OH)D than D2, even if limited to daily dose studies, but D2 and D3 had similar positive impacts on their corresponding 25(OH)D hydroxylated forms. BMI should be considered when comparing the effect of daily vitamin D2 and vitamin D3 supplementation on total 25(OH)D concentration.STATEMENT OF SIGNIFICANCE: Previous meta-analyses suggest that vitamin D3 may be more potent in increasing serum 25(OH)D concentrations than vitamin D2. In addition, it appeared that with daily dosing this difference is smaller compared to other doses, e.g. monthly/bolus. Our meta-analysis confirms this when comparing the commonly recommended more frequent dosing regimens, daily versus weekly, although residual heterogeneity remained high. BMI and baseline 25(OH)D concentration may contribute to this residual variability and may therefore be considered when recommending a daily intervention with vitamin D2 or D3.PMID:37865222 | DOI:10.1016/j.advnut.2023.09.016
Source: Adv Data - Category: Epidemiology Authors: Source Type: research