A timely, user-friendly, and flexible marker-assisted speed congenics method

In this study, we present 255 microsatellites and 10 RFLPs which can be used in 18 marker panels, allowing the easy and fast introgression of genes of interest from three mouse lines commonly used for transgenesis (C57BL/6, 129/Sv and FVB) to six mouse lines relevant for biomedical research (BALB/c, C3H, DBA/1, DBA/2, SJL and SWR/J). In addition, our markers analysis confirmed a recently described lack of isogeny in well-established inbred mouse lines available from commercial breeders.PMID:37843753 | DOI:10.1007/s11248-023-00365-7

Source: Transgenic Research - October 16, 2023 Category: Genetics & Stem Cells Authors: Anne-Sophie Van Laere Audrey Tromme Laetitia Delaval Fr édéric Farnir Jo ël Blomet Daniel Desmecht Source Type: research