PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells

This study discovered that CS significantly elevates PSAT1 expression in bronchial epithelial cells. Further studies using autophagy inhibitor, RNA interference, RT-qPCR, western blot, and CCK-8 assay in 16-HBE cells have confirmed that autophagy is temporarily initiated by cigarette smoke extract, but insufficient autophagy leads to cell death. PSAT1 induced by CSE promotes autophagy and resists insufficient autophagy caused by CSE through Akt/mTOR pathway in human bronchial epithelial cells, playing a protective role.PMID:37832835 | DOI:10.1016/j.tiv.2023.105711

Source: Toxicology in Vitro - October 13, 2023 Category: Toxicology Authors: Lixing Wang Furong Yan Yongbin Shi Yifei Liu Xiaoshan Su Yaping Zhang Source Type: research