Lewis acid-promoted direct synthesis of isoxazole derivatives

Abstract Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition metals and presents a novel pathway for the synthesis of isoxazole derivatives. Beilstein J. Org. Chem. 2023, 19, 1562–1567. doi:10.3762/bjoc.19.113
Source: Beilstein Journal of Organic Chemistry - Category: Chemistry Authors: Tags: aluminum trichloride Lewis acid isoxazole derivatives sodium nitrite transition metals Full Research Paper Source Type: research