Elucidating the Role of PIK3CA in Early-Stage Bladder Tumorigenesis

More than 70% of bladder cancers are nonmuscle invasive bladder cancers.1 Despite the high prevalence of nonmuscle invasive bladder cancers, there are significant gaps in our  understanding of the early stages of bladder tumorigenesis. A landmark study by Shuman et al2 addresses this critical knowledge gap, focusing on the role of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA)–activating mutations, identified across different stages of bladder cancer as one of the most prevalent oncogenic mutations.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Commentary Source Type: research