"Andrographolide, Diterpenoid constituent of Andrographis paniculata: Review on Botany, Phytochemistry, Molecular docking analysis, and Pharmacology"

Ann Pharm Fr. 2023 Oct 7:S0003-4509(23)00111-6. doi: 10.1016/j.pharma.2023.10.001. Online ahead of print.ABSTRACTAndrographis paniculata (kalmegh) is also known as "king of bitters", is an herbaceous plant belongs to family Acanthaceae. The therapeutic effect is due to presence of diterpenoid lactone derivatives of Andrographis paniculata mainly andrographolide.The main purpose of this review includes detailed (past and present) study of Andrographis paniculata and its most important component andrographolide a diterpenoid lactone with respect to its botany, phytochemistry, molecular docking analysis and pharmacological effects i.e., therapeutic benefits. In reference to the search, we also compiled variety of dosage forms available which are made up of Andrographis paniculata extract and Andrographolide such as tablets and capsules. This review also discusses reported methods of extraction of phytoconstituents, pharmacokinetics of main components, their molecular docking analysis data and main therapeutic applications with their proposed mechanism of actions in various diseases. According to data collected Andrographis paniculata is becoming more and more valuable as a therapeutic herb.PMID:37813330 | DOI:10.1016/j.pharma.2023.10.001
Source: Annales Pharmaceutiques Francaises - Category: Drugs & Pharmacology Authors: Source Type: research