Emergence of SARS-CoV-2 variant of interest B.1.525 (Eta) in Bangladesh

Biologicals. 2023 Oct 5;84:101714. doi: 10.1016/j.biologicals.2023.101714. Online ahead of print.ABSTRACTIn the present study, we report the complete genome of five Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from Bangladesh harboring mutations at Spike protein (E484K, Q677H, D614G, A67V, Q52R, Y144del, H69del, V70del, F888L) assigned to the B.1.525 lineage (Variant of interest). Mutations are also found in viral structural proteins other than spike region (E_L21F, M_I82F, N_A12G and N_T208I) and other mutations (NSP3_T1189I, NSP6_S106del, NSP6_F108del, NSP6_G107del, NSP12_P323F) from all of five B.1.525 SARS-CoV-2 variants of Bangladesh. We have also found four unique mutations from two of SARS-CoV-2 B.1.525 variant of Bangladesh. Among the four unique mutations two mutations (NS7a_L96H, NS7a_Y97D) obtained from strain BCSIR-NILMRC-718, one (NSP3_A1430V) from BCSIR-NILMRC-738 and two mutation including one spike protein mutation (NSP2_L444I, Spike_I68 M) present in BCSIR-AFIP-10 strain. The identification of new mutations will contribute to characterizing SARS-CoV-2, to continue tracking its spread and better understanding its biological and clinical features to take medical countermeasures and vaccines.PMID:37804694 | DOI:10.1016/j.biologicals.2023.101714

Source: Biologicals : Journal of the International Association of Biological Standardization - October 7, 2023 Category: Biotechnology Authors: Barna Goswami Md Murshed Hasan Sarkar Shahina Akter Tanjina Akhtar Banu Iffat Jahan Md Saddam Hossain Mohammad Mohi Uddin Tasnim Nafisa Md Maruf Ahmed Molla Mahmuda Yeasmin Eshrar Osman Mohammad Samir Uzzaman Abu Sayeed Mohammad Mahmud Ahashan Habib Salim Source Type: research