Proteasome inhibition protects blood –brain barrier P-glycoprotein and lowers Aβ brain levels in an Alzheimer’s disease model

Loss of P-glycoprotein (P-gp) at the blood –brain barrier contributes to amyloid-β (Aβ) brain accumulation in Alzheimer’s disease (AD). Using transgenic human amyloid precursor protein (hAPP)-overexpressing mic...

Source: Cerebrospinal Fluid Research - October 6, 2023 Category: Neurology Authors: Milica Vulin, Yu Zhong, Bryan J. Maloney, Bj örn Bauer and Anika M. S. Hartz Tags: Research Source Type: research