Mechanistic insight into the adjuvant effect of co-exposure to ultrafine carbon black and high humidity on allergic asthma

This study aims to investigate the adjuvant effect of ultrafine carbon black (30 –50 nm) and high humidity (70% relative humidity) on the induction of allergic asthma. A mouse model of asthma was established using ovalbumin, and airway hyperresponsiveness, remodeling, and inflammation were measured as the endpoint effects of asthma. The mediating role of the oxidative stress p athway and the transient receptor potential vanilloid 1 pathway in asthma induction was validated using pathway inhibitors vitamin E and capsaicin, respectively. Co-exposure to ultrafine carbon black and high humidity had a significant impact on metabolic pathways in the lung, including aminoacyl-tR NA biosynthesis, glycerophospholipid metabolism, and ATP-binding cassette transporters. However, administering vitamin E and capsaicin altered the effects of co-exposure on the lung metabolome. These results offer new insights into the health risk assessment of co-exposure to environmental risk fact ors and provide an important reference point for the prevention and treatment of allergic asthma.Graphical abstract
Source: Environmental Geochemistry and Health - Category: Environmental Health Source Type: research