Back to the future: targeting the extracellular matrix to treat systemic sclerosis

Nature Reviews Rheumatology, Published online: 03 October 2023; doi:10.1038/s41584-023-01032-1The autoimmune disease systemic sclerosis is characterized by fibrosis, which is poorly targeted by the use of anti-inflammatory and immunosuppressive drugs. In this Review, the authors describe the fibrotic mechanisms underlying SSc and attempts to develop drugs to specifically target the fibrotic extracellular matrix.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research