P319 Histopathological features and autophagy aspects of Ku+ myositis

Ku+ myositis is one of the rarer forms of myositis, with antibodies that are associated with many forms of connective tissue disease and the clinical picture of the patients often varies. A few histopathological examinations have shown a broad picture with inflammatory or necrotizing aspects, but a precise description and characterization of Ku+ myositis is still lacking. Therefore, the aim of this study was to perform a detailed histopathological and transcriptional examination of muscle samples from Ku+ patients with myositis to uncover possible pathophysiological mechanisms/commonalities.

Source: Neuromuscular Disorders - October 1, 2023 Category: Neurology Authors: C. Preusse, M. Holzer, U. Schneider, A. Sch änzer, S. Léonard-Louis, O. Benveniste, J. Weis, K. Claeys, B. Schoser, F. Montagnese, A. Uruha, M. Huber, L. Gallay, N. Streichenberger, K. Mrusche, W. Stenzel Tags: MYOSITIS Source Type: research