P323 Differences in clinicopathology and therapeutic response of idiopathic inflammatory myopathy with anti-SRP, HMGCR, and mitochondrial M2 antibodies

Anti-SRP and anti-HMGCR antibodies are pathologically often associated with immune-mediated necrotizing myopathy (IMNM). In addition, myositis with anti-mitochondrial M2 antibody has been also classified as IMNM. The purpose of this study is to characterize the clinical course, muscle pathology and treatment response of them. We selected the patients with idiopathic inflammatory myopathy with anti-SRP (SRP), HMGCR (HMGCR), and AMA-M2 (AMA) antibodies who underwent muscle biopsy at our department between 2011 and 2020, and analyzed clinical findings, muscle pathology, and treatment course.

Source: Neuromuscular Disorders - October 1, 2023 Category: Neurology Authors: A. Yamanaka, N. Eura, Y. Nihimori, T. Shiota, H. Nanaura, T. Kiriyama, T. Izumi, H. Kataoka, K. Sugie Source Type: research