P335 Inhibition of KDM5A reverses pathological features in sporadic Inclusion Body Myositis-like cell models

Sporadic Inclusion Body Myositis (sIBM) is the most common acquired myopathy in adults over the age of 50 and characterised by inflammatory and degenerative processes leading to progressive muscle weakness and physical disability. In an in-house proteomics study, KDM5A, a histone demethylase, was found as key upstream regulator in sIBM patients whole muscle lysates, interconnecting with hallmark processes in sIBM, and hypothesised as disease master regulator. KDM5A overactivity and inhibition was studied in sIBM-like cell models, incubating human myoblasts with inflammatory cytokines (IL-1 β and TNFα) or through APP overexpression.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research