Drug discovery and therapeutic perspectives for proximal tubulopathies
The efficient reabsorption of essential nutrients by epithelial cells in the proximal tubule of the kidney is crucial for maintaining homeostasis. This process heavily relies on a complex ecosystem of vesicular trafficking pathways. At the center of this network, the lysosome plays a pivotal role in processing incoming molecules, sensing nutrient availability, sorting receptors and transporters, and balancing differentiation and proliferation in the tubular epithelial cells. Disruptions in these fundamental processes can lead to proximal tubulopathy − a condition characterized by the dysfunction of the tubular cells followed by the presence of low molecular weight proteins and solutes in the urine.
Source: Kidney International - Category: Urology & Nephrology Authors: Svenja Keller, Zhiyong Chen, Anna Gaponova, Mikhail Korzinkin, Marine Berquez, Alessandro Luciani Tags: mini review Source Type: research
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