Single cell RNA sequencing sheds light on infiltrating T cells in idiopathic inflammatory myopathies

EMBO Mol Med. 2023 Sep 28:e18190. doi: 10.15252/emmm.202318190. Online ahead of print.ABSTRACTIdiopathic inflammatory myopathies (IIM), also referred to as "myositis," are a group of heterogeneous autoimmune disorders characterised by muscle weakness, atrophy and progressive reduced mobility (Lundberg et al, 2021). IIM represent a significant health burden in adult populations, affecting individuals at a mean age of 50 with an estimated prevalence of 2.9-34 per 100,000 (Dobloug et al, 2015; Svensson et al, 2017). IIM encompass several subtypes including dermatomyositis, immune-mediated necrotising myopathy, inclusion-body myositis, antisynthetase syndrome and polymyositis, which are characterised by specific clinical features, histopathological findings and autoantibody status (Pinal-Fernandez et al, 2020).PMID:37768011 | DOI:10.15252/emmm.202318190

Source: Molecular Medicine - September 28, 2023 Category: Molecular Biology Authors: Momina Yazdani Lukas Mach Michela Noseda Source Type: research