Postoperative pain after root canal filling with bioceramic sealers: a systematic review and meta-analysis of randomized clinical trials
OdontologyPublished:28 June 2023Odontologyvolume 111, pages793 –812 (2023)AbstractThe
aim of this systematic review and meta-analysis (SRM) was to assess
postoperative pain (PP) after endodontic treatment with bioceramic root
canal sealer compared to AH Plus ® sealer. This SRM was carried out in
accordance with the items on the PRISMA 2020 checklist and Cochrane
guidelines and registered in PROSPERO (CRD42021259283). Only randomized
clinical trials (RCTs) were included. Meta-analysis was conducted using R
software, the standardized means difference (SMD) measure of effect was
calculated for quantitative variables, and the odds ratio (OR) for
binary variables. The Cochrane tool (RoB 2.0) was used to assess the
risk of bias, and the Grading of Recommendations Assessment,
Development, and Evaluation (GRADE) approach was used to assess the
q uality of evidence. Qualitative and quantitative analysis included 18
and 17 studies, respectively. For quantitative variables, the bioceramic
root canal sealer presented less occurrence of postoperative pain than
the AH Plus® sealer in 24 h (SMD − 0.17 [ − 0.34; − 0.01],p = 0.0340).
For binary variables, there was no difference observed between the
sealers evaluated, except for sealer extrusion where the bioceramic
group had lower post-filling material extrusion (OR 0.52 [0.32; 0.84],p = 0.007).
Regarding the risk of bias analysis, low risk was observed for most
domains, exc...
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