Incorporation of inosine into DNA by human polymerase eta (Pol η): kinetics of nucleotide misincorporation and structural basis for the mutagenicity

This study demonstrates that TLS incorporation of inosine monophosphate (IMP) into growing DNA chains contributes to its mutagenic potential in cells.PMID:37746864 | DOI:10.1042/BCJ20230159

Source: The Biochemical Journal - September 25, 2023 Category: Biochemistry Authors: Qi Zhang Natalia Tretyakova Source Type: research