Fluid shear stress enhances dendritic cell activation

In this study, dendritic cells were activated by sustained exposure to circulatory levels of fluid shear stress using a cone-and-plate flow device and analyzed for activation markers. After 1 h of shear stress exposure, an increase in cytokine release was present in immortalized cells as well as phosphorylation of the proteins NF-κB and cFos in primary DCs. Changes in DC morphology, metabolism and proliferation were also observed. These compelling new findings point to the potential for using FSS to activate DCs for ex vivo therapeutics.PMID:37729773 | DOI:10.1016/j.imbio.2023.152744

Source: Immunobiology - September 20, 2023 Category: Allergy & Immunology Authors: Jenna A Dombroski Schyler J Rowland Abigail R Fabiano Samantha V Knoblauch Jacob M Hope Michael R King Source Type: research