Renin-angiotensin-aldosterone system inhibitors as a risk factor for chronic subdural hematoma recurrence: A matter of debate

Chronic subdural hematoma (cSDH) is a common central nervous system condition. Recent reports indicate that cSDH affects long-term prognosis; however, its definitive risk factors remain unknown. An antihypertensive drug, renin –angiotensin–aldosterone system inhibitors (RAASi), can affect vascular permeability and cell proliferation processes, which may suppress the recurrence of cSDH. However, several studies have reported negative results to this effect. Therefore, we aimed to evaluate antihypertensive drugs, includ ing RAASi, as risk factors for recurrent cSDH.

Source: Journal of Stroke and Cerebrovascular Diseases - August 12, 2023 Category: Neurology Authors: Wataru Shimohigoshi, Hajime Takase, Tatsuya Haze, Yusuke Kobayashi, Hiroshi Manaka, Takashi Kawasaki, Katsumi Sakata, Tetsuya Yamamoto Source Type: research