The Pharmacokinetics of Individual Conjugated Xanthohumol Metabolites Show Efficient Glucuronidation and Higher Bioavailability of Micellar than Native Xanthohumol in a Randomized, Double ‐Blind, Crossover Trial in Healthy Humans

ConclusionMetabolism of orally ingested xanthohumol is complex and efficiently converts the parent compound to predominantly glucuronic acid and to a lesser extent sulfate conjugates. The oral bioavailability of micellar xanthohumol is superior to native xanthohumol, making it a useful delivery form for future human trials.

Source: Molecular Nutrition and Food Research - September 19, 2023 Category: Food Science Authors: Lance Buckett, Nadine Sus, Veronika Spindler, Michael Rychlik, Christian Schoergenhofer, Jan Frank Tags: Research Article Source Type: research