Prospects and challenges of CRISPR/Cas9 gene-editing technology in cancer research

Clin Genet. 2023 Sep 14. doi: 10.1111/cge.14424. Online ahead of print.ABSTRACTCancer, one of the leading causes of death, usually commences and progresses as a result of a series of gene mutations and dysregulation of expression. With the development of clustered regularly interspaced palindromic repeat (CRISPR)/Cas9 gene-editing technology, it is possible to edit and then decode the functions of cancer-related gene mutations, markedly advance the research of biological mechanisms and treatment of cancer. This review summarizes the mechanism and development of CRISPR/Cas9 gene-editing technology in recent years and describes its potential application in cancer-related research, such as the establishment of human tumor disease models, gene therapy and immunotherapy. The challenges and future development directions are highlighted to provide a reference for exploring pathological mechanisms and potential treatment protocols of cancer.PMID:37706265 | DOI:10.1111/cge.14424
Source: Clinical Genetics - Category: Genetics & Stem Cells Authors: Source Type: research