Caecum OX40+CD4 T-cell subset associates with mucosal damage and key markers of disease in treated HIV-infection

CONCLUSION: High frequencies of caecum OX40+CD4 T-cells are found in people with HIV (PWH) and successful viral control. Interestingly, this cellular subset reflects key markers of disease and peripheral T-cell activation, as well as HIV-driven mucosal damage. OX40+CD4 T-cells deserve further investigation since they could expand because of T-cell homeostatic proliferation and relate to the Th22/Th17 gut mucosal ratio.PMID:37704537 | DOI:10.1016/j.jmii.2023.08.011

Source: Journal of Microbiology, Immunology, and Infection - September 13, 2023 Category: Microbiology Authors: Isaac Rosado-S ánchez In és Herrero-Fernández Salvador Sobrino Ana E Carvajal Miguel Genebat Laura Taranc ón-Díez Mar ía Carmen Garcia-Guerrero Mar ía Carmen Puertas Roc ío M de Pablos Roc ío Ruiz Javier Martinez-Picado Manuel Leal Yolanda M Pach Source Type: research