Synthesis of β-Hydroxyhydrophosphonic Acids from Inorganic Sodium Hypophosphite

Synthesis DOI: 10.1055/a-2133-1963 An efficient approach to access β-hydroxyhydrophosphonic acid derivatives is reported by ring-opening reaction of readily available epoxides with green, inexpensive, and safe inorganic salt sodium hypophosphate as the phosphorus source in the presence of silver trifluoromethanesulfonate as the catalyst. The reaction is achieved under simple operation and exhibits excellent selectivity as well as good functional group compatibility. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Synthesis - Category: Chemistry Authors: Tags: feature Source Type: research