GI highlights from the literature

Basic scienceMacrophage and neutrophil heterogeneity in human inflammatory bowel disease Garrido-Trigo A, Corraliza A, Veny M, et al. Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease. Nat Commun 2023: 14(1):4506. doi: 10.1038/s41467-023-40156-6. Patients with underlying ulcerative colitis (UC) and Crohn’s disease (CD) have heterogeneous differences in clinical manifestations and response to treatments. The molecular basis for this heterogeneity remains uncharacterised. Garrido-Trigo et al applied single-cell RNA sequencing and CosMx Spatial Molecular Imaging to human inflamed tissue to try and unravel the underlying mechanisms behind this heterogeneity. Using colonic samples from six healthy controls, six patients with UC and six patients with CD, Garrido-Trigo et al, found the highest diversity in cellular composition was in the myeloid compartment of patients with UC and CD. Resident macrophages were closest to mucosal surface in healthy controls whereas remodelling of myeloid compartment was evident with M1...
Source: Gut - Category: Gastroenterology Authors: Tags: Gut JournalScan Source Type: research