Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8+ T cells

Conclusion
Metabolism of HBV-specific and HCV-specific T cells is strongly connected to their exhaustion severity. Our results highlight enolase as metabolic regulator of severely exhausted T cells. They connect differential bioenergetic fitness with distinct exhaustion subtypes and varying liver disease, with implications for therapeutic strategies.

Source: Gut - September 13, 2023 Category: Gastroenterology Authors: Winkler, F., Hipp, A. V., Ramirez, C., Martin, B., Villa, M., Neuwirt, E., Gorka, O., Aerssens, J., Johansson, S. E., Rana, N., Llewellyn-Lacey, S., Price, D. A., Panning, M., Gross, O., Pearce, E. L., Hermann, C. M., Schumann, K., Hannibal, L., Neumann-H Tags: Open access, Gut Hepatology Source Type: research