GSE242923 miRNA expression profile from Adipocyte-derived Small Extracellular Vesicles from the Serum and cerebrospinal fluid of Alzheimer Disease Patients and Controls

Contributors : Rachael A Batabyal ; Ankush Bansal ; Laura Reck Cechinel ; Kayla Authelet ; Madeleine Goldberg ; Evan Nadler ; C D Keene ; Suman Jayadev ; Kimiko Domoto-Reilly ; Gail Li ; Elaine Peskind ; Kazue Hashimoto-Torii ; Dedra Buchwald ; Robert J FreishtatSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructMidlife obesity increases the risk of developing AD. Adipocyte-derived small extracellular vesicles (ad-sEVs) have been implicated as a mecha-nism in several obesity-related diseases. We hypothesized that ad-sEVs from patients with AD would contain miRNAs predicted to downregulate pathways involved in synaptic plasticity and memory formation. We isolated ad-sEVs from the serum and cerebrospinal fluid (CSF) of patients with AD and controls and compared miRNA expression profiles
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research