Macrolide esterases: current threats and opportunities

Trends Microbiol. 2023 Sep 7:S0966-842X(23)00238-X. doi: 10.1016/j.tim.2023.08.008. Online ahead of print.ABSTRACTAntibiotics often contain ester bonds. The macrocyclic lactones of macrolides are pre-eminent examples in which ester bonds are essential to the form and function of antibiotics. Bacterial macrolide esterases that hydrolyze these macrocyclic lactones to confer antimicrobial resistance (AMR) are the topic of this forum. We provide insight into their role in agricultural systems and discuss their emergence and their potential extensibility to bioremediation efforts.PMID:37689489 | DOI:10.1016/j.tim.2023.08.008
Source: Trends in Microbiology - Category: Microbiology Authors: Source Type: research