Expression of microRNA-379 reduces metastatic spread of prostate cancer

DiscussionTaken together, our in vitro and in vivo functional assays support a role for miR-379 as a tumour suppressor. A potential mechanism is unravelled whereby miR-379 deregulation in PCa cells affects the secretion of GDF-15 from osteoblasts which in turn facilitates the metastatic establishment in bone. Our findings support the potential role of miR-379 as a therapeutic solution for prostate cancer.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research