Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions

In conclusion, cholinergic detrusor contraction and RhoA activation are mediated by both M2 and M3 receptors. Furthermore, whereas both Gαi and Gαq/11 proteins mediate UBSM contraction, the activation at the RhoA-ROCK pathway appears to be linked specifically to Gαi. These findings may aid the identification of more specific therapeutic targets for bladder dysfunctions.PMID:37675459 | DOI:10.1152/ajprenal.00261.2022

Source: Am J Physiol Renal P... - September 7, 2023 Category: Urology & Nephrology Authors: Helga Balla Kinga Borsodi Petra Őrsy B éla Horváth P éter József Molnár Ádám Lénárt M ónika Kosztelnik Éva Ruisanchez J ürgen Wess Stefan Offermanns P éter Nyirády Zolt án Benyó Source Type: research