Age-related cytokine imbalance in the thymus in sudden infant death syndrome (SIDS)

CONCLUSIONS: Elevated thymic cytokine expression and thymus weight, as well as impaired age-related alterations in SIDS, may be influenced by subclinical infection, which may play a role in initiating SIDS in infants with a compromised immune response.IMPACT STATEMENT: Increased thymic weight and cytokine concentration may suggest possible subclinical infection in SIDS. Elevated thymic weight and cytokine concentration mainly in SIDS cases aged <20 weeks. Age-related impairment in the thymic weight and cytokine expression may be impaired by subclinical infection in SIDS.PMID:37679518 | DOI:10.1038/s41390-023-02809-6

Source: Pediatric Research - September 7, 2023 Category: Pediatrics Authors: Dong Qu Vanessa Preuss Lars Hagemeier Lena Radomsky Kerstin Beushausen Jana Keil Schaumann Nora Benedikt Vennemann Christine S Falk Michael Klintschar Source Type: research