In vitro effects of Gla-domainless factor Xa analog on procoagulant and fibrinolytic pathways in apixaban-treated plasma and whole blood

Andexanet alfa is a Gla-domainless FXa (GDXa) analog used as an antidote to FXa inhibitors. Despite its clinical use, laboratory monitoring for anti-Xa reversal and the effect of andexanet on fibrinolysis has not been explored. We used a GDXa with a serine-to-alanine mutation at position 195 (chymotrypsin numbering) to model the interaction between andexanet and apixaban.

Source: Thrombosis Research - September 8, 2023 Category: Hematology Authors: Rui Terada, Penny M. Johnson, Amir Butt, Yuko Mishima, Kenneth E. Stewart, Jerold H. Levy, Kenichi A. Tanaka Tags: Full Length Article Source Type: research