From fetal tendon regeneration to adult therapeutic modalities: TGF- β3 in scarless healing

Regen Med. 2023 Sep 6. doi: 10.2217/rme-2023-0145. Online ahead of print.ABSTRACTTendon injuries are common disorders that can significantly impact people's lives. Unfortunately, the limited regenerative ability of tendons results in tissue healing in a scar-mediated manner. The current therapeutic strategies fail to fully recover the functions of the injured tendons, and as such, the conception of 'scarless healing' has gained prominent attention in the field of regenerative medicine. Interestingly, injured fetal tendons possess the capability to heal through regeneration, which builds an ideal blueprint for adult tendon regeneration. Studies have shown that fetal biochemical cues have the potential to improve adult tendon healing. Here we review the biological factors that contribute to fetal tendon regeneration and how manipulation of these biochemical cues in the adult tendon healing process could achieve regeneration.PMID:37671630 | DOI:10.2217/rme-2023-0145

Source: Regenerative Medicine - September 6, 2023 Category: Genetics & Stem Cells Authors: Hanyue Li Shengyu Luo Hongtao Li Hongyu Pan Li Jiang Yixuan Chen Hui Chen Zhenhua Feng Sen Li Source Type: research