An atlas of genome-wide gene expression and metabolite associations and possible mediation effects towards body mass index

In conclusion, here, we present the largest available multi-omics integration of genome-wide transc riptome data and metabolite data of amino acid and fatty acid metabolism and further leverage these findings to characterize potential mediation effects towards BMI proposing candidate mechanisms of obesity and related metabolic diseases.Key messagesThousands of associations of 72 amino acid and acylcarnitine metabolites and 8579 genes expand the knowledge of metabolome-transcriptome associations.A mediation analysis of effects on body mass index revealed large mediation networks of thousands of obesity-related gene-metabolite pairs.Highly connected, potentially mediating hub genes and metabolites enabled insight into obesity and related metabolic disease pathomechanisms.
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research