Antibody-mediated PCSK9 neutralization worsens outcome after bare-metal stent implantation in mice

CONCLUSION: Antibody-based PCSK9 inhibition promotes in-stent intimal hyperplasia and blunts vascular healing by increasing VSMC migration, while reducing that of EC. This effect is likely mediated, at least in part, by a differential effect on VSMC and EC senescence. The herein-reported data warrant additional investigations concerning the use of PCSK9 inhibitors in patients undergoing PCI with stent implantation.PMID:37659608 | DOI:10.1016/j.vph.2023.107170

Source: Vascular Pharmacology - September 2, 2023 Category: Drugs & Pharmacology Authors: Yustina M Puspitasari Stefano Ministrini Luca Liberale Ana Vukolic Philine Baumann-Zumstein Erik W Holy Fabrizio Montecucco Thomas F L üscher Giovanni G Camici Source Type: research