Functional and molecular profiling of hematopoietic stem cells during regeneration

Hematopoietic stem cells (HSCs) support lifelong production of mature blood cells and need to be precisely regulated to ensure a balance between mature cellular output and long-term sustainability. While HSCs are the only hematopoietic cells that harbor both self-renewal and long-term multilineage capacity, they do not constitute a homogenous population. Subtle differences in lineage priming and reconstitution potential create a continuum of non-discrete HSC subtypes 1-4. Similarly, the differentiation of HSCs into more restricted progenitors is a gradual, rather than stepwise, process 5, 6.

Source: Experimental Hematology - September 2, 2023 Category: Hematology Authors: Anna Rydstr öm, Tan HM Grahn, Abhishek Niroula, Els Mansell, Mark van der Garde, Maroulio Pertesi, Agatheeswaran Subramaniam, Shamit Soneji, Roman Zubarev, Tariq Enver, Björn Nilsson, Kenichi Miharada, Jonas Larsson, Stefan Karlsson Tags: Article Source Type: research