Black cumin ethanolic extract reduce aortic intima media thickness due to cigarette smoke exposure in experimental rats

Background and Aims: Cigarette smoking could induce pro-atherogenic changes seen in endothelial cells and increase inflammation markers due to oxidative stress. This can lead to increased intima media thickness of blood vessel and accelerate atherosclerosis. Black cumin (Nigella sativa) may inhibit oxidative stress. Aim of this study is to explore the link between cigarette smoking exposure to endothelial-nitric oxide synthase and vascular cell adhesion molecule-1 as well as the protective effects of black cumin in reducing aortic intima media thickness caused by cigarette smoking.

Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: R.A. Nugraha, B.P. Khrisna, T. Putra, L.G. Rinjani, M. Ardiana, I.G. Suryawan, B. Pikir Source Type: research