Separating friend from foe; inhibition of TGF- β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes

In this study we aimed to block TGF-β-induced SMAD1/5/9 signaling in primary human OA chondrocytes, while maintaining functional SMAD2/3 signaling.

Source: Osteoarthritis and Cartilage - August 29, 2023 Category: Rheumatology Authors: Nathalie G.M. Thielen, Arjan P.M. van Caam, Henk M. v. Beuningen, Elly L. Vitters, Martijn H.J. van den Bosch, Marije I. Koenders, Fons A.J. van de Loo, Esmeralda N. Blaney Davidson, Peter M. van der Kraan Source Type: research